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[Preprint]. 2023 Sep 25:rs.3.rs-3356170. [Version 1] doi: 10.21203/rs.3.rs-3356170/v1

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The average microbiome and metabolome diversity of subjects in this study. A) Average change in the alpha-diversity (Shannon index) of lung microbiome and metabolome of pwCF on/off ETI treatment per day. B) Average of the beta-diversity of the lung microbiome and metabolome of pwCF before and after ETI per day. Weighted UniFrac distance was used for microbiome data and Bray-Curtis dissimilarity for metabolome data. P-values obtained from Wilcoxon test are displayed. Scatterplots of the predicted vs. observed C) microbiome and D) metabolome association with the time in days since pwCF started on ETI treatment. This data was obtained from RF regression analysis of each individual subject as well as their Pearson correlation tests.