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View full-text article in PMC

. 2023 Oct 9;15(19):4900. doi: 10.3390/cancers15194900

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MBL2 inhibits HCC proliferation, migration, and invasion in vitro. (A) Fluorescence was used to show the transfection efficiency of lentiviruses carrying the MBL2 gene and the green fluorescent protein tag. (B,C) qPCR and Western blot assays were conducted to validate the successful establishment of MBL2 overexpression in Huh7 and BEL-7404 cell lines. (D,E) CCK-8 (D) and plate colony assays (E) were used to evaluate the effects of MBL2 on suppressing HCC proliferation. (F,G) Transwell (F) and wound healing assays (G) were used to assess the inhibitory effects of MBL2 on HCC migration and invasion (** p < 0.01, *** p < 0.001, **** p < 0.0001). MBL2, mannose-binding lectin 2; HCC, hepatocellular carcinoma; CCK-8, cell counting kit-8.