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. 2023 Sep 26;12(19):2358. doi: 10.3390/cells12192358

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Polyarginine CPPs inhibit SERCA2 isoforms. Oxalate-supported Ca²⁺ uptake was assessed in homogenates of HEK293 cells transfected with SERCA1 (A), SERCA3 (B), SERCA2a (C), or SERCA2b (D). Effects of Arg₉ or Arg₁₁ incubation were compared with untreated homogenates. Data are presented as mean ± SEM. Statistical analyses were performed by one-way ANOVA with Tukey’s post hoc correction. p values are indicated versus Ctr. NS = not statistically significant. N_runs in Ctr, Arg₉, Arg₁₁ = 4, 5, 5 for SERCA1 transfected cells; 4, 5, 5 for SERCA3; 12, 16, 16 for SERCA2a; and 12, 12, 12 for SERCA2b. Homogenates were made from 5–15 dishes of transfected cells in each case.