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. 2023 Sep 30;12(19):2391. doi: 10.3390/cells12192391

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Hematopoietic differentiation triggered by vitamin D. The epigenome modulating effect of vitamin D (via the VDR with the help of PU.1 and CEBPα) modulates the differentiation of immune cells during hematopoiesis (top). In parallel, many immune challenges influence this differentiation process in the bone marrow as well as in the periphery. The stabilization of the epigenomes of the subtypes of monocytes and T cells (bottom) contributes to the prevention or delaying the onset of diseases including MS.