Figure 5.

Comparison of WNT4 gene expression in a patient cohort from the Uterine Corpus Endometrial Carcinoma database in the TCGA repository. (A) Groups with altered WNT4 and ESR1 gene expression overlapped. Colors denote selected groups, and numbers indicate the corresponding number of patients. Groups that exhibited altered expressions of both genes (WNT4 and ESR1) overlapped. (B) Histogram of the frequency of changes in WNT4 gene expression for each specific cancer type (green—mutations, red—gene amplification, blue—deep deletion, pink—high mRNA). (C) Comparison of clinical characteristics with WNT4 gene expression z-scores relative to all samples. Disease-free status (DFS; (D)) and overall survival (OS; (E)) curves of patients with unchanged and altered gene expression.