TABLE 2.
MICs of β-lactam drugs for S. typhimurium clinical isolates and E. coli derivatives
| Strain | MIC (μg/ml)a
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AMP | AMC | SAM | TIC | TIM | PIP | PTZ | CAZ | CTX | ATM | IPM | FOX | |
| S. typhimurium strains | ||||||||||||
| 28 | >128 | 16 | 64 | >128 | 128 | >128 | 2 | 8 | 128 | 32 | 0.25 | 2 |
| 34 | >128 | 32 | 64 | >128 | >128 | >128 | 64 | 8 | 128 | 32 | 0.25 | 2 |
| E. coli strains | ||||||||||||
| DH5α | 8 | 8 | 8 | 4 | 1 | 1 | 0.25 | 0.25 | ≤0.12 | ≤0.12 | 0.25 | 8 |
| DH5α/pCLL2300 | 8 | 8 | 8 | 4 | 1 | 1 | 0.25 | 0.25 | ≤0.12 | ≤0.12 | 0.25 | 8 |
| DH5α/pCLL3422 + pCLL2300 | >128 | 64 | 32 | >128 | 128 | 128 | 8 | 1 | 0.5 | 0.5 | 0.5 | 8 |
| DH5α/pCLL3425 | >128 | 32 | 32 | >128 | 128 | >128 | 1 | 16 | >128 | 128 | 0.5 | 16 |
| DH5α/pCLL3417 | >128 | 32 | 64 | >128 | 128 | >128 | 0.5 | 16 | >128 | 128 | 0.5 | 8 |
a
MICs were determined in broth microdilution tests (21). AMP, ampicillin; AMC, amoxicillin-clavulanate; SAM, ampicillin-sulbactam; TIC, ticarcillin; TIM, ticarcillin-clavulanate; PIP, piperacillin; PTZ, piperacillin-tazobactam; CAZ, ceftazidime; CTX, cefotaxime; ATM, aztreonam; IPM, imipenem; FOX, cefoxitin.