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A simplified schema of the proposed model. At 5 months post-injection, PrPC-positive HSCs in ME7-infected middle-aged mice show cell-autonomous apoptosis. At 7 months post-injection, both PrPC-negative and -positive HSCs in ME7-infected old-aged mice become senescent due to selective deterioration of the BM microenvironment with aged phenotypes of increased adipogenesis and osteoclastogenesis via a non-cell-autonomous mechanism.
