FIG. 1.

(A) Rats with acute P. carinii infections were treated s.c. b.i.d. for 4 days with 0.075, 0.038, 0.019, or 0.009 mg of MK-991 per kg. There were five rats in each group. The ED₉₀ was estimated to be 0.011 mg/kg. (The limit of detection was 4.66.) (B) Mice with acute P. carinii infections were treated s.c. b.i.d. for 4 days with various doses of MK-991. There were five mice in each group. The ED₉₀ was determined to be 0.02 mg/kg. (The limit of detection was 3.36.)