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Trophozoite clearance in rats. Rats with acute P. carinii infections treated for 21 days with 1 mg of MK-991 per kg b.i.d. or Bactrim in water were evaluated for trophozoites with a P. carinii-specific DNA probe. Rats in the MK-991-treated group showed a 66.3% reduction in the level of trophozoites, while rats in the Bactrim-treated group showed a 99.9% reduction in the number of trophozoites.
