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Oral efficacy in rats. Rats with acute P. carinii infections were gavaged b.i.d. for 4 days with 0.78, 0.163, 3.13, or 6.25 mg of MK-991 per kg. Each group contained five rats. The ED90 was estimated to be 2.2 mg/kg. (The limit of detection was 4.66.)
