Figure 6.

In vivo anti-tumor efficacy in human NSCLC xenografted nude mouse models. The H460-FLuc xenografted nude mice were treated with ADC (12 and 16 mg/kg CD276 mAb-MMAF) or saline (control) via i.v. injection through the tail vein. (A) Tumor volume post-treatment is indicated by a black arrow. Tumor volume was measured with calipers and calculated as an ellipsoid. Data were presented as mean ± SEM. n = 5. * p < 0.05 vs. saline. Saline (○), 12 mg/kg of anti-CD276 mAb (■), and 24 mg/kg of ADC (♦). (B) Profiles of body weight.