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. 2023 Sep 23;15(19):4689. doi: 10.3390/cancers15194689

Figure 1.

Figure 1

Scheme of the structural and functional regions of the estrogen receptor (ER). (A) Comparison of the domain topology of ERα and ERβ. The homology of the ERα and ERβ receptors was determined based on the amino acid sequence retrieved from the UniProt database (https://www.uniprot.org/; accessed on 12 March 2023; ESR1 ID: P03372, ESR2 ID: Q92731). AF1—the activation of function domain 1; DBD—the DNA-binding domain; H—hinge region; LBD—ligand-binding domain; AF2—the activation of function domain 2; A/B—the domains located at the N-terminus (N); C—the domain containing zinc-finger; D—the domain with nuclear localization signal; E/F—the domains located at the C-terminus (C). (B) Diagram of the estrogen receptor dimer binding to DNA in the estrogen-response elements (ERE). A-F as explained in the description of A; Lig—ligand.