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. 2023 Sep 23;15(19):4689. doi: 10.3390/cancers15194689

Figure 2.

Figure 2

Genomic and non-genomic action of estrogen receptor (ER). Abbreviations: A/B—the domains of ER located at the N-terminus of estrogen receptor (N); C—the domain containing zinc-finger; E/F—the domains located at the C-terminus; GPER—G protein-coupled estrogen receptor 1; PI3K—phosphatidylinositide 3-kinase; AKT—serine/threonine kinase; mTOR—the mammalian target of rapamycin; cAMP—cyclic adenosine monophosphate; PLC—phospholipase C; IP3—inositol trisphosphate; IP3R—inositol trisphosphate receptor; HSP90—heat shock protein 90; ERE—estrogen-response element; TF—transcription factor.