Table 1.

Estimated PK parameters for trontinemab and gantenerumab in NHPs.

Name		Cynomolgus monkey		Human
	Units	Trontinemab	Gantenerumab	Trontinemab (projected)	Gantenerumaba
Vcen	mL/kg	45.4	50.8	45.4	50.3
CL	mL/h/kg	1.01	0.537	0.680	0.200
Vper	mL/kg	63.2	97.1	63.2	91.1
Q	mL/h/kg	0.746	2.86	0.502	0.517

Projected PK parameters for trontinemab in humans obtained by allometric scaling from NHPs and estimated human PK parameters for gantenerumab.

^aOriginal parameters were transformed to different units (mL instead of L, h instead of day) and normalized by body weight (assuming 70 kg).

CL, clearance; NHP, non-human primate; Q, intercompartmental exchange clearance; PK, pharmacokinetic; V_cen, central volume; V_per, peripheral volume.