Table 2.
microRNA | Regulation | Activated or Inhibitted Cellular Function of CD44 | References |
---|---|---|---|
miR-21 | positive | Activation: Proliferation, stemness, invasion, chemotherapy resistant | [76,77,78,80,81,82] |
Inhibition: senescence, apoptosis | [83] | ||
miR-10b | positive | Activation: Invasion, migration, EMT, drug resistance | [61,84,85,86,93] |
miR-302 | positive | Activation: stemness | [87,88,89,90,92] |
miR-373 | negative | Inhibition: proliferation, invasion | [94] |
miR-520s | |||
miR-138 | negative | Inhibition: proliferation, cell cycle, migration, wound-healing ability | [95] |
EMT; epithelial-to-mesenchymal transition.