Table 1.
Details of selected ZOL-1 responder and non-responder human-derived glioblastoma tumor cell lines.
| Glioblastoma (GS) Sample ID * | Responder/Non-Responder | New/Recurrent | Ethnicity | Sex (M/F) | Age | EGFR CNV | PTEN CNV | PTEN MUT |
|---|---|---|---|---|---|---|---|---|
| GS054 | Non-Responder | Recurrent | White | F | 59 | Shallow Deletion | G44D | |
| GS122 ** | Non-Responder | Recurrent | White | M | 40 | Amplified | Shallow Deletion | |
| GS147 *** | Non-Responder | Recurrent | White | M | 59 | Amplified | Shallow Deletion | |
| GS154 | Non-Responder | Recurrent | Latino | M | 51 | Copy Number Gain | ||
| GS194 + | Non-Responder | Recurrent | White | M | 52 | Amplified | Shallow Deletion | |
| GS023 | Responder | New | Mexican | F | 47 | X342_splice | ||
| GS025 | Responder | Recurrent | White | F | 39 | Amplified | ||
| GS118 + | Responder | Recurrent | White | M | 74 | Shallow Deletion | ||
| GS152 & | Responder | New | Black | M | 61 | Shallow Deletion | N292Kfs*6 | |
| GS130 $ | Responder | Recurrent | White | F | 61 | Shallow Deletion | X70_splice |
* All cases diagnosed were glioblastoma, IDH-wildtype; ** GS122 had detected EGFR vIII expression; *** GS147 had a PIK3CA mutation (E39K); + GS194 (A289V) and GS118 (R108K) had EGFR mutations; & GS152 tumor line was xenografted into mice to establish the GBX1152 tumor line; $ GS130 tumor line was xenografted into mice to establish the XDS4130 tumor line.