TABLE 1.
Bacterial inocula used in the systemic infection model
Challenge strain | Dilutiona | Inoculum size (CFU/mouse) | No. of LD50sb |
---|---|---|---|
S. aureus MB2985 | 1:25 BHB | 2 × 107 | 65 |
S. pneumoniae MB212 | 1:105 BHB | 8 × 102 | 572 |
S. pneumoniae MCL4997 | 1:25 BHB | 1.9 × 106 | 510 |
S. pneumoniae MCL4983 | 1:25 BHB | 1.9 × 106 | 140 |
S. pneumoniae MCL5631 | 1:25 BHB | 1.4 × 106 | 11 |
S. pyogenes MB2874 | 1:106 BHB | 1.9 × 102 | 91 |
E. cloacae MB2646 | 1:5 × 103 HGM | 1.4 × 105 | 9 |
E. coli MB2884 | 1:105 HGM | 3.5 × 103 | 572 |
K. pneumoniae MB2883 | 1:5 × 103 HGM | 1.6 × 105 | 516 |
M. morganii MB2833 | 1:5 × 105 HGM | 5.3 × 102 | 104 |
P. aeruginosa MB2835 | 1:5 × 104 HGM | 5.2 × 104 | 215 |
P. aeruginosa MB3286 | 1:5 × 104 HGM | 3.3 × 104 | 19 |
P. mirabilis MB3125 | 1:104 HGM | 2.6 × 105 | 297 |
S. marcescens MB3548 | 1:5 × 102 HGM | 1.3 × 106 | 1,400 |
Bacterial cultures diluted in either BHB or 5% hog gastric mucin (HGM).
Challenge inoculum size equals this multiple of the LD50 inoculum.