TABLE 4.

Distribution of MK-826 and CTRX in tissue in mice following a 10-mg/kg i.p. dose^a

Tissue	AUC0–∞ (μg · hr/ml)
	MK-826	CTRX
Kidney	19.98	18.24
Liver	16.75	22.23
Lung	21.82	31.89
Spleen	6.33	8.38
Thigh	6.86	7.80
Heart	17.18	16.65
Brain	1.80	NDb

^aDistribution in tissue determined by high-performance liquid chromatography. Tissue samples were obtained from a group of five mice for each period. 

^bND, not defined.