Table 1.

Heteroplasmic Sites and frequency in two inbred mouse strains at 14- and 112-days post-V₂O₅ exposure. Heteroplasmic site * Indicates a nonsynonymous mtDNA variant at a given position in the mitochondrial genome. B6, C57BL/6J; D2, DBA/2J; PBS, phosphate-buffered saline; V₂O₅, vanadium pentoxide; heteroplasmic site, a position in the mitochondrial genome where the amino acid sequence changes ≥ 1% in a sample population; heteroplasmy frequency, combined percent heteroplasmy frequency in the specified group according to strain, exposure, and time. n = 3–4/group.

Strain	Exposure	Time Point	Position	Reference Base	Gene Name	Heteroplasmy Frequency
D2	PBS	14	4405	A	mt-Nd2	8.9%
D2	PBS	14	11,879	T	mt-Nd5	2.8%
D2	V2O5	14	11,879	T	mt-Nd5	8.1%
B6	PBS	14	13,052	T	mt-Nd5	3.0%
B6	V2O5	14	14,992 *	C	mt-Cytb	1.3%
D2	V2O5	112	1054	G	mt-Tv	2.7%
D2	PBS	112	2781 *	G	mt-Nd1	10.3%
B6	V2O5	112	5228	G	mt-Tc	7.2%
B6	V2O5	112	9214 *	T	mt-Co3	4.1%
B6	V2O5	112	9461	T	mt-Nd3	26.0%
D2	PBS	112	11,879	T	mt-Nd5	20.2%
B6	V2O5	112	13,270 *	A	mt-Nd5	1.1%
D2	V2O5	112	15,446	A	D-loop	1.4%

* Nonsynonymous mtDNA variant.