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. 2023 Sep 25;24(19):14515. doi: 10.3390/ijms241914515

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Hierarchical clustering heat map of the expression of differentially expressed circulating miRNAs after hydrocortisone administration. The log2 fold-change value of 73 miRNAs with a significant variation of |log2 fold-change| ≥ 1 by small RNA-seq was indicated in the dendrogram of the hierarchical clustering heat map. Fold changes were calculated as log2 (after administration/time-matched control). The miRNAs in yellow and violet indicate high and low expression, respectively. The log2 fold-change of chr3_33188 was out of range at −11.37 at 3 h and 8.66 at 12 h after administration.