Table 3.

Differentially expressed circulating miRNAs after hydrocortisone administration.

miRNA 1	Time after the Administration (h)	Small RNA-seq		RT-qPCR
		Level 2	log2 Fold-Change	Level 2	log2 Fold-Change	p-Value
chr3-33188	12	↑	8.66	↑	0.78	0.028
chrX-47614	48	↑	4.19	↑	1.10	0.028
chr20-23348	12	↑	3.48	-	−0.17	0.249
chrX-47606	36	↑	3.34	-	−0.04	0.753
miR-133a	3	↑	2.98	↑	1.25	0.028
miR-206	9	↑	2.75	-	−0.09	0.463
miR-1	3	↑	2.63	↑	1.29	0.046
chr3-32616	6	↑	2.48	-	−0.12	0.249
miR-122	48	↑	2.32	↑	2.88	0.028
chr7-41424	9	↑	2.12	-	0.40	0.116
chr3-33188	3	↓	−11.37	-	0.13	0.345
chr25-30007	12	↓	−4.14	↓	−2.69	0.028
miR-532-3p	9	↓	−2.04	-	0.33	0.116
miR-451	6	↓	−1.93	↓	−1.42	0.028
miR-7	6	↓	−1.80	↓	−0.78	0.046
miR-144	6	↓	−1.69	-	−0.22	0.249
chr7-42879	12	↓	−1.59	↓	−2.90	0.028
miR-142-3p	36	↓	−1.48	-	−0.30	0.075
let-7a	48	↓	−1.47	-	−0.61	0.075
miR-200b	12	↓	−1.46	-	−0.43	0.173

¹ List of the top 20 miRNAs most altered by hydrocortisone administration in small RNA-seq and their variations by RT-qPCR. The “chr” at the beginning of the name indicates novel miRNAs and the chromosome numbers where they are present. ² Level indicates an increase (↑) or decrease (↓) in miRNA levels after hydrocortisone administration. The “-” indicates no significant difference.