Figure 3.

SUN11602 reduced mast cell infiltration in spinal cord tissue. The SCI caused the recruitment of mast cells in the damage site (B,F) than in the control group (A,F). Only at a dose of 5 mg/kg was SUN11602 capable of reducing the number of mast cells (E,F), in comparison with SUN11602 at 1 mg/kg (C,F) or 2.5 mg/kg (D,F) doses, which were ineffective. Yellow circles indicate the mast cells. Images are displayed at 40× magnifications. Data are expressed as mean ± SD where N = 10 mice for each group. One–Way ANOVA test. *** p < 0.001 vs. Sham; ^### p < 0.001 vs. SCI.