Table 2.

Summary of the selected terms affected by ISS, CBD, and cisplatin treatments in the HCT-116 CRC cell line. Data are based on mRNA expression data as analyzed by Reactome analysis with PathfindR. All names of terms are as per PathfindR. ISS—intermittent serum starvation; DMSO—dissolves cisplatin and allows it to enter the cell; thus, the control group contained DMSO alone in order to analyze the effect of cisplatin on cells.

ISS vs. Untreated		CBD vs. DMSO		Cisplatin vs. DMSO
Term	Fold Enrichment	Term	Fold Enrichment	Term	Fold Enrichment
ERBB2 activates PTK6 signaling	9.8	Receptor-type tyrosine-protein phosphatases	23.1	TP53 regulates transcription of cell death genes	41.5
PI3K events in ERBB4 signaling	9.1	Xenobiotics	17.3	TP53 regulates transcription of cell cycle genes	37.4
NGF-stimulated transcription	8.4	Regulation of gene expression by hypoxia-inducible factor	17.3	Syndecan interactions	37.4
ERBB2 regulates cell motility	7.3	Activation of the AP-1 family of transcription factors	17.3	TP53 regulates transcription of genes involved in G2 cell cycle arrest	34.0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	6.3	TP53 regulates transcription of death receptors and ligands	14.5	Intrinsic pathway of apoptosis	31.1
RAF-independent MAPK1/3 activation	5.5	Downregulation of TGF-ß signaling	13.3	Response of EIF2AK4 (GCN2) to amino acid deficiency	27.7
MAPK targets/nuclear events mediated by MAP kinases	4.2	FOXO-mediated transcription of cell cycle genes	10.2	TP53 regulates metabolic genes	24.9
Signaling by EGFR in cancer	3.8	Downregulation of TGF-ß signaling	13.3	Cellular response to starvation	24.9
NOTCH3 intracellular domain regulates transcription	3.8	Glucose metabolism	7.9	FOXO-mediated transcription	24.9
Interferon α/β signaling	3.4	PPARα activates gene expression	6.0	POU5F1 (OCT4), SOX2, and NANOG activate genes related to proliferation	10.4