Table 1.

Findings Suggestive of Pulmonary Hypertension in Interstitial Lung Disease.

History	Syncope Dizziness Palpitations History of pulmonary embolism
Exam Findings	Jugular venous distension Peripheral edema Ascites Altered heart sounds (especially loud P2 or S2 heart sound) Hepatomegaly
Functional Testing	Severely reduced or worsening 6MWD Marked or worsening exertional desaturations Decreased heart rate recovery after exercise (<13 beats)
CT Imaging	RV:LV ratio >1 Increased PA:A ratio (>0.9)
Echocardiography	RV dilation Reduced TAPSE (<16 mm) RVOT diameter >3.4 cm Reduced RV fractional area change (<35%) Reduced RV ejection fraction on 3D echocardiography
PFTs	Severely reduced DLCO (<30%)
Laboratory Testing	Elevated BNP or NT-proBNP

Legend: 6MWD = six-minute walk distance, RV = right ventricle, LV = left ventricle, PA = pulmonary artery, A = aorta, TAPSE = tricuspid annular plane systolic excursion, RVOT = right ventricular outflow tract, 3D = three dimensional, BNP = brain naturetic peptide, NT-proBNP = N-terminal pro-brain naturetic peptide.