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KLF15 attenuates the ubiquitin-mediated degradation of NRF2. (A–D) KLF15 knockdown HK2 and HEK 293 cells and control cells were treated with 10 μM of MG132 or DMSO for 2 h, and Western blot analysis was then performed to assess the protein expression of KLF15, NRF2, and GAPDH (loading control). KLF15, Krüppel-like factor 15; NRF2, nuclear factor erythroid 2-related factor 2; HK2, human tubular epithelial cells. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
