Table 3.

Comparison of monoamines levels in the cervical and lumbar spinal cord between the groups receiving L-DOPA alone or combined with nialamide or tolcapone. The group L-DOPA 25 serves as reference for the multiple comparison.

	L-DOPA				Dopamine
	Cervical		Lumbar		Cervical		Lumbar
Kruskal-Wallis test	p Value		p Value		p Value		p Value
	<0.0001		<0.0001		<0.0001		<0.0001
Dunn’s multiple comparisons		p Value		p Value		p Value		p Value
L-DOPA 25 vs.
L-DOPA 25 + Tolc. 30	↘	<0.0001		0.4001		0.8183		0.3636
L-DOPA 25 + Tolc. 100		0.4795	↗	<0.0001	↗	0.0005	↗	<0.0001
L-DOPA 25 + Nial. 100		0.0574	↗	0.0182	↗	<0.0001	↗	<0.0001
	DOPAC				Noradrenaline
	Cervical		Lumbar		Cervical		Lumbar
Kruskal-Wallis test	p Value		p Value		p Value		p Value
	<0.0001		<0.0001		0.0004		<0.0001
Dunn’s multiple comparisons		p Value		p Value		p Value		p Value
L-DOPA 25 vs.
L-DOPA 25 + Tolc. 30	↗	0.0010	↗	0.0009	↗	0.0022	↗	0.0007
L-DOPA 25 + Tolc. 100	↗	<0.0001	↗	<0.0001	↗	0.0038	↗	<0.0001
L-DOPA 25 + Nial. 100	↘	0.0377		0.1099	↗	0.0021		0.6740
	5-HT				5-HIAA
	Cervical		Lumbar		Cervical		Lumbar
Kruskal-Wallis test	p Value		p Value		p Value		p Value
	<0.0001		<0.0001		0.0104		<0.0001
Dunn’s multiple comparisons		p Value		p Value		p Value		p Value
L-DOPA 25 vs.
L-DOPA 25 + Tolc. 30		>0.9999		0.6024		0.1986	↘	0.0366
L-DOPA 25 + Tolc. 100		0.3188		0.2760		0.4940		0.2319
L-DOPA 25 + Nial. 100	↗	<0.0001	↗	<0.0001		>0.9999		0.2503