TABLE 1.
Characteristics of the patients investigateda
| Pa- tient | Age (yr), sex | Wt (kg) | Disease | Time interval (days)b | Treatment | Serum creatinine concn (mg/dl) | CLCRc (ml/min) | Serum albumin concn (g/liter) | CSF analysisd
|
|||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Protein concn (mg/liter) | QAlb (10−3) | WBC/ mm3 | RBC/ mm3 | |||||||||
| 1 | 48, m | 85 | Intracerebral hemorrhage | 4 | Amoxicillin, clavulanate, gentamicin, metronidazole | 1.7 | 64 | 28 | 425 | 5.4 | 91 | 8,875 |
| 2 | 75, f | 70 | Subarachnoid hemorrhage | 12 | 0.7 | 76 | 23 | 284 | 5.3 | 5 | 20 | |
| 3 | 63, m | 80 | Intracerebral hemorrhage | 4 | Mannitol | 0.7 | 122 | 27 | 1,630 | 29.9 | 68 | 2,560 |
| 4 | 75, f | 75 | Cerebellar hemorrhage | 7 | Mannitol | 0.8 | 72 | 28 | 848 | 10.1 | 5 | 1,605 |
| 5 | 55, f | 85 | Subarachnoid hemorrhage | 8 | Dexamethasone, mannitol | 0.7 | 121 | 27 | 518 | 3.0 | 26 | 4,096 |
| 6 | 52, m | 70 | Basilar artery occlusion | 3 | Mannitol, amoxicillin, gentaicin, metronidazole | 0.8 | 107 | 26 | 201 | 4.4 | 1 | 40 |
| 7 | 63, f | 80 | Infratentorial infarction | 5 | Mannitol, amoxicillin, clavulanate | 0.9 | 81 | 29 | 80 | 1.5 | 0 | 20 |
| 8 | 66, m | 95 | Intracerebral hemorrhage | 11 | Mannitol, cefotaxime, metronidazole | 0.8 | 122 | 31 | 1,716 | 4.9 | 11 | 4,690 |
| 9 | 55, m | 95 | Intracerebral hemorrhage | 8 | Dexamethasone | 0.7 | 160 | 29 | 840 | 7.8 | 44 | 7,851 |
| 10 | 60, f | 65 | Intracerebral hemorrhage | 8 | Glycerol, cefotaxime | 0.9 | 68 | 22 | 843 | 6.1 | 3 | 1,840 |
a
Patient order reflects descending peak CSF meropenem concentration.
b
Time interval between insertion of external ventriculostomy and the first meropenem infusion.
c
Creatinine clearance (CLCR) was estimated by the following equations: males, (140 − age) · weight · 72−1 · serum creatinine−1; females, (140 − age) · weight · 85−1 · serum creatinine−1. These equations tend to overestimate creatinine clearance in obese and emaciated patients.
d
WBC, leukocyte; RBC, erythrocyte.