TABLE 2.
Kinetic properties of meropenem in serum after i.v. administration of 2 g
| Patient | Cmax (mg/l) | AUC (mg · h/liter) | CL (ml/min) | CL/kg (ml/min/kg) | t1/2β (h) | Vβ (liter) | VSS (liter) | VSS/kg |
|---|---|---|---|---|---|---|---|---|
| 1 | 90.6 | 210.6 | 158 | 1.86 | 2.72 | 37.2 | 31.9 | 0.38 |
| 2 | 132.4 | 305.1 | 109 | 1.56 | 2.34 | 22.2 | 19.8 | 0.28 |
| 3 | 96.1 | 206.4 | 162 | 2.03 | 1.11 | 15.5 | 28.1 | 0.35 |
| 4 | 80.5 | 234.3 | 142 | 1.89 | 2.32 | 28.6 | 26.4 | 0.35 |
| 5 | 82.1 | 91.2 | 365 | 4.29 | 1.32 | 41.8 | 24.6 | 0.29 |
| 6 | 90.6 | 135.1 | 247 | 3.53 | 1.24 | 26.5 | 25.2 | 0.36 |
| 7 | 56.9 | 130.0 | 256 | 3.20 | 1.96 | 43.5 | 34.5 | 0.43 |
| 8 | 101.6 | 97.1 | 343 | 3.61 | 1.01 | 30.0 | 19.9 | 0.21 |
| 9 | 65.6 | 60.7 | 549 | 5.78 | 1.44 | 68.7 | 37.8 | 0.40 |
| 10 | 51.0 | 90.2 | 369 | 5.68 | 1.41 | 45.2 | 38.9 | 0.60 |
| Mean (± SD)a | 84.7 (23.7) | 156.1 (78.9) | 270 (137) | 3.34 (1.55) | 1.69 (0.60) | 35.9 (15.0) | 28.7 (6.8) | 0.37 (0.10) |
| Median | 86.4 | 132.6 | 252 | 3.37 | 1.43 | 33.6 | 27.3 | 0.36 |
a
SD, standard deviation.