Table 10.

Conditions for triggering alerts on subset of variables from the data collection journey.

Variable	Description	Pilot Study	Alert Conditions
Domain I—Mobility, general motor or physical function
Step count, periods of relative immobility/slowness of movement	Continuously monitored step count and other features of general mobility in daily life	PD, MS, Stroke	Reduction of week average ≥ 20%
Self-assessed questionnaire for muscle tone	Self-assessed questionnaire to quantify the muscle tone variable	Stroke	Increase of ≥1 point compared to previous month
ACTIVLIM questionnaire	Self-assessed questionnaire to examine both upper and lower limb muscle strength using daily living activities	Stroke	When answer to a question changes from “easy” to “difficult” or “impossible”, compared to previous month
Dizziness and Balance questionnaire	Self-assessed questionnaire for the balance variable	Stroke	When a patient checks a symptom that was not checked in the previous month
Domain II—Sleep disorders
Pittsburgh Sleep Quality Index (PSQI)	Self-administered questionnaire to assess sleep patterns	PD, MS, Stroke	Change in answer to item 5, marking an increase in occurrence frequency compared to previous month
Domain III—Mental and cognitive ability
Virtual Supermarket Test	Self-administered test based on a 3D serious game to assess cognitive decline	PD	Deterioration of performance by ≥20% compared to test 3 months ago
Domain IV—Emotional status
PHQ-9	Monitor the severity of depression and response to the treatment	MS, Stroke	Score increase of ≥1 point compared to previous month
Domain V—Quality of life and daily living
MFIS	Assessment of the effects of fatigue in terms of physical, cognitive and psychosocial functioning	PD, MS, Stroke	Score increase of ≥16 points or ≥19% compared to previous month