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Molecular mechanisms modulated by dietary polyphenols in IBD. The figure summarizes the inhibitory effects of plant polyphenols on NF-kB (non-dashed line), a key transcription factor for pro-inflammatory genes, and the activating effects on Nrf2 (dashed line), the main transcriptional regulator of several detoxification and antioxidant enzymes. Modulation of these pathways from polyphenols could represent an alternative therapeutic strategy for IBD.
