Table 6.
Malignant potential with SUV value of 18F-fluorodeoxyglucose positron emission tomography.
| Study | n | Inclusion Criteria of Tumor |
Treatment (n) | Point of View | Evaluation | Results |
|---|---|---|---|---|---|---|
| Lee et al. [75] | 59 | Milan criteria (within/beyond) | LTP | TSUVmax/LSUVmax (cutoff value; 1.15) |
Outcome (recurrence) | Significantly difference was seen about recurrence-free survival. TSUVmax/LSUVmax < 1.15; the 1 year and 2 year recurrence-free survival rate was 97% and 97%, respectively. TSUVmax/LSUVmax ≥ 1.15; the 1 year and 2 year recurrence-free survival rate was 57% and 42%, respectively. |
| Detry et al. [76] | 27 | Milan criteria (within/beyond) | LTP | TSUVmax/LSUVmax (cutoff value; 1.15) |
Outcome (recurrence, OS) | TSUVmax/LSUVmax > 1.15 was one of the independent factors for recurrence-free survival (HR, 14.4; p = 0.01) and overall survival (HR, 5.62; p = 0.04). |
| Hong et al. [77] | 123 | Milan criteria (within/beyond) | LTP | TSUVmax/LSUVmax (cutoff value; 1.10) |
Outcome (recurrence, OS) | TSUVmax/LSUVmax > 1.10 was an independent factor for recurrence (HR, 9.776; 95% CI, 3.557–26.816; p < 0.001). |
| HSU et al. [78] | 147 | “Solitary and ≤6.5 cm” or “≤3 tumors and ≤4.5 cm” and total tumor diameter ≤8 cm |
LTP | TNR (cutoff value; 2.0) |
Outcome (recurrence) | TNR ≥ 2.0 was one of the independent factors for recurrence (HR, 13.52; 95% CI, 4.77–38.29; p < 0.001). |
| Hyun et al. [79] | 317 | BCLC stage 0 or A | Curative treatment (LR or RFA or LTP) (195) TACE (122) |
TLR (cutoff value; 2.0) |
Outcome (recurrence, OS) | TLR ≥ 2.0 was an independent factor for OS in curative treatment group (HR, 2.68; 95% CI, 1.16–6.15; p = 0.020). |
| Cho et al. [80] | 56 | Early stage | LR | SUVmax (cutoff value; 4.9) |
Outcome (recurrence, OS) | SUVmax was not significant independent factor for recurrence (p = 0.262) and OS (p = 0.717). |
| Hyun et al. [81] | 158 | BCLC stage 0 or A | LR | TLR (cutoff value; 1.3) |
Microvascular invasion Outcome (recurrence) |
Predictability of TLR for microvascular invasion as follows: sensitivity was 85.5%, specificity was 54.9%, positive predictive value was 63.7%, negative predictive value was 80.4%. TLR was one of the independent factors for metastatic recurrence (HR, 2.43; 95% CI, 1.01–5.84; p = 0.047). |
| Yoh et al. [82] | 207 | Solitary | LR | TNR (cutoff value; 2.0) |
Outcome (recurrence, OS) | TNR was one of the independent factors for OS (HR, 1.743; 95% CI, 1.114–2.648; p = 0.016). |
CI: confidence interval; HR: hazard ratio; LR: liver resection; LSUV: liver SUV; LTP: liver transplantation; OS: overall survival; PET: positron emission tomography; RFA: radiofrequency ablation; SUV: standardized uptake values; TLR: tumor to normal liver SUV ratio; TNR: tumor to nontumor ratio; TSUV: tumor SUV.