TABLE 1.
Susceptibilities of S. pneumoniae ATCC 49619 (parent strain) and norfloxacin-selected mutants to fluoroquinolones and efflux pump substrates
| Compound | Range of (median) MICs (μg/ml)
|
||
|---|---|---|---|
| Parent strain | Presumptive efflux mutants (n = 5) | Non-efflux mutants (n = 18) | |
| Norfloxacin | 4 | 16–32 (16) | 16–32 (16) |
| Norfloxacin + reserpine | 4 | 4–8 (4) | 16 |
| Ciprofloxacin | 0.5 | 2–4 (2) | 2–4 (2) |
| Sparfloxacin | 0.5 | 0.25–0.5 (0.5) | 0.5 |
| Moxifloxacin | 0.12 | 0.12–0.25 (0.12) | 0.12 |
| Ethidium bromide | 4 | 16–32 (16) | 4 |
| Acriflavine | 4 | 32 | 4 |