Figure 1.

Brain and serum SZR72 levels. SZR72 treatment resulted in similar SZR72 levels in all examined brain regions (Fcx—frontal cortex, Ocx—occipital cortex, HIP—hippocampus, CN—caudate nucleus, MED—medulla oblongata), and there were no significant differences among the assessed brain regions. The data from the individual brain regions were also compared with serum levels obtained at 12–24 h after beginning of SZR72 administration, and the data indicating good blood–brain barrier penetration, as SZR72 concentrations in the hippocampus and the caudate were not significantly different from the serum values. Lines, boxes, and whiskers represent the median, the interquartile range, and the 10th–90th percentiles, respectively. * p < 0.05 significantly different from the serum values.