TABLE 1.
Effect of treatment with paclitaxel on DNA synthesis by HFF
| Expt no. | Time in culture | Paclitaxel dose (μM) | DNA synthesis (cpm)a
|
P value | |
|---|---|---|---|---|---|
| Without paclitaxelb | With paclitaxel | ||||
| 1 | 24 h | 7,987 ± 278 | |||
| 1 | 8,071 ± 790 | 7,158 ± 992 | 0.24c | ||
| 5 | 9,865 ± 150 | 7,459 ± 381 | 0.12c | ||
| 10 | 10,166 ± 739 | 7,232 ± 1,088 | 0.31c | ||
| 2 | 24 h | 2,689 ± 190 | |||
| 1 | 2,881 ± 589 | 3,038 ± 356 | 0.21c | ||
| 5 | 2,468 ± 183 | 3,044 ± 526 | 0.33c | ||
| 10 | 2,665 ± 566 | 3,115 ± 414 | 0.18c | ||
| 3 | 8 days | 2,379 ± 366 | |||
| 0.25 | 1,687 ± 582 | 0.16d | |||
| 0.5 | 1,969 ± 447 | 0.29d | |||
| 1 | 2,314 ± 866 | 0.91d | |||
a
Demonstrated by uptake of [3H]thymidine.
b
Where no paclitaxel dose is given, results are for HFF cultured in medium alone. Where a paclitaxel dose is given, the results are for HFF cultured in medium with the same amount of diluent as used with the paclitaxel.
c
P value for comparison of results with cultures of HFF treated with paclitaxel and HFF cultured with the corresponding amount of diluent in medium.
d
P value for comparison of results with cultures of HFF treated with paclitaxel and HFF cultured with medium.