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. 2023 Sep 28;24(19):14710. doi: 10.3390/ijms241914710
ACO asthma-COPD overlap
ACO ovalbumin + elastase protocol
ACO-DX treated with dexamethasone
ACO-DX-pep3-EcTI treated with dexamethasone and peptide
ACO-pep3-EcTI treated with inhibitor
ACO-like model model used in Ikeda research
AS alveolar septa
AW airways
BALF bronchoalveolar lavage fluid
BSA bovine serum albumin
CD8+ T cluster of differentation 8
CNPq National Council for Scientific and Technological Development
COPD chronic obstructive pulmonary disease
DAB diaminobenzidine chromogen
ECM extracellular matrix
EcTI Enterolobium contortisiliquum
ELA elastase protocol
eNO exhaled nitric oxide
%Ers respiratory system elastance
FAPESP research support foundation of the State of São Paulo
FEV1 forced expiratory volume in first second
GINA Global Initiative of Asthma
GOLD Global Initiative for Chronic Obstructive Lung Disease
%Gtis tissue resistance system
%Htis tissue elastance system
ICS inhaled corticosteroid
IFN-γ interferon gamma
IgE immunoglobulin E
IL-1β interleukin 1Beta
IL-4 interleukin 4
IL-5 interleukin 5
IL-6 interleukin 6
IL-10 interleukin 10
IL-13 interleukin 13
IL-17 interleukin 17
IL-17F interleukin 17 A
IL-17F interleukin 17 F
IL-22 interleukin 22
iNOS inducible nitric oxide synthase
IP intraperitoneal
Lm linear mean intercept
LIM-20 Laboratory of Experimental Therapy I
MMP´s Metalloproteinases
MMP-9 metalloproteinase 9
MMP-12 metalloproteinase 12
NF-κB nuclear factor kappa-B
NO nitric oxide
OVA ovalbumin protocol
PBS Phosphate-buffered Saline
pep3-EcTI Peptide EcTI
PKa human plasma kallikrein
ppb parts per billion
PPE porcine pancreatic elastase
%Raw airway resistance system
%Rrs respiratory system resistance
SAL saline protocol
SAL-pep3- EcTI saline group treated with peptide
TGF-β transforming growth factor beta
Th2 T-helper cells 2
Th17 T-helper cells 17
TNF-α tumor necrosis fator alpha