Figure 3.

Graphical representation of potential mechanisms that contribute to the WOLI-mediated follicle growth. The WOLI procedure could lead to (1) disruption of the Hippo signaling pathway, (2) stimulation of angiogenic pathways, increased supply of oxygen, nutrients, and various growth factors, and (3) tissue remodeling and associated immune responses, which altogether help rejuvenate the ovarian environment in an atretic ovary. Growing follicles are indicated by the presence of replicating granulosa cells (i.e., yellow cells surrounding the oocytes).