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. 2023 Sep 30;24(19):14785. doi: 10.3390/ijms241914785

Figure 6.

Figure 6

Profile of the type and composition of nanodiscs present on the vitrification step of membrane protein structures solved by using cryo-EM single-particle analysis below 3.0 Å resolution in the last two years (2021–2022) available in the Protein Data Bank. (A) Profile of the type of nanodiscs used in the vitrification step. Membrane scaffold proteins (MSP)-based nanodiscs: MSP1E3D1, MSP2N2, and MSP1D1. Salipro: saposin–lipid–protein complexes. SMA: Styrene–maleic acid copolymer (native nanodiscs). (B) Profile of the lipid component of MSP-based nanodiscs. E. coli TLE: Total lipid extract of E.coli. SPLE: soybean polar lipid extract. BTLE: brain total lipid extract. Others include POPG + POPE + cholesterol (1 report); BTLE + POPE (1 report); asolectin lipids (1 report), DOPC + DOPE + cardiolipin (1 report), yeast polar lipid extract (1 report); PC + PG + cholesterol (1 report), POPG (1 report), no info (1 report). POPC associations include: POPC + POPE + POPG (3 reports in 3:1:1 ratio), POPC + POPE + cholesterol (1 report), and POPC + POPG (1 report).