FIG. 5.

Histograms showing the size distributions (FSC-H; left panels) and nucleic acid contents (FL2-H; middle panels) of P. aeruginosa during the PAE after exposure to imipenem at a concentration equivalent to twice the MIC and to ciprofloxacin at a concentration equivalent to the MIC at 180 and 70 min after drug removal, respectively. Dotted-and-dashed lines, control organisms; solid lines, antibiotic-exposed organisms. The graphs (right panels) show progressive changes in size compared to sizes of controls. The sizes of antibiotic-treated organisms were compared to three control size intervals described in text and shown in Fig. 2. Open circles, bacteria within 2 SDs of control size; solid squares, bacteria within 2 to 4 SDs; open squares, organisms >4 SDs from the control distribution.