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DSB repair pathways and their activity throughout the cell cycle. DNA end resection is the main delimiter of DSB repair pathway engagement. Thus, DSB repair pathways are categorized as DNA end resection independent (c-NHEJ) and DNA end resection dependent (HR, alt-EJ, and SSA). C-NHEJ operates with similar efficiency throughout the entire cell cycle, while HR, alt-EJ, and SSA are more active in S- and G2-phase, where resection activities are typically higher.
