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. 2023 Sep 30;24(19):14808. doi: 10.3390/ijms241914808

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Intermittent hypoxia-exposed M2-type macrophage supernatant enhanced glycolysis and upregulated HK1 expression. (A–D) The lactate and pyruvate contents of laryngeal carcinoma cells were measured. (E) The intersection of DEGs and glycolysis-related genes is shown in a Venn diagram. (F,G) The HK1 mRNA level in laryngeal carcinoma cells treated with normal or IH-exposed M2-type macrophage supernatant was measured by qPCR. (H,I) Representative Western blot images showing HK1 protein levels. The data are presented as the mean ± SD values. * p < 0.05; ** p < 0.01; *** p < 0.001.