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. 2023 Sep 30;24(19):14794. doi: 10.3390/ijms241914794

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Intracellular APP trafficking. (1) APP transcription in the nucleus and mRNA export to the cytoplasm. (2) APP mRNA translation on a ribosome with the assistance of SRP or unestablished targeting factors (no experimental evidence of SRP involvement yet, thus, it is indicated by a question mark). (3) The transport of nascent APP to ER for further biogenesis. (4) The transition to Golgi for post-translational modifications. (5) The transport of full-length APP to mitochondria and the insertion into the mitochondria membrane. (6) The transport of full-length APP to the plasma membrane (PM). (7) The internalization of full-length APP into the endosomal system for further cleavage.