Table 2.

Association of CERT with study endpoints.

		Overall Mortality		Cardiovascular Mortality		MACE
		HR [IQR]	p	HR [IQR]	p	HR [IQR]	p
CERT categories (4 steps)	Model 1	1.351 [1.157–1.578]	<0.001	1.427 [1.123–1.812]	0.004	1.255 [1.062–1.482]	0.008
	Model 2	1.259 [1.074–1.476]	0.005	1.349 [1.055–1.726]	0.017	1.225 [1.033–1.452]	0.020
	Model 3	1.265 [1.079–1.484]	0.004	1.360 [1.062–1.741]	0.015	1.221 [1.026–1.452]	0.024
	Model 4	1.215 [1.035–1.427]	0.017	1.304 [1.018–1.670]	0.035	1.167 [0.981–1.388]	0.081
CERT (13 steps)	Model 1	1.089 [1.040–1.140]	<0.001	1.124 [1.046–1.207]	0.001	1.062 [1.010–1.117]	0.019
	Model 2	1.067 [1.019–1.118]	0.006	1.105 [1.027–1.188]	0.007	1.065 [1.013–1.119]	0.014
	Model 3	1.068 [1.019–1.120]	0.006	1.105 [1.027–1.188]	0.008	1.062 [1.010–1.117]	0.019
	Model 4	1.055 [1.007–1.106]	0.024	1.090 [1.014–1.172]	0.020	1.049 [0.998–1.103]	0.061

Hazard ratios (HR) with the interquartile range (IQR) of Cox regressions are summarized applying different adjustment models. Model 1 represents an unadjusted regression. Model 2 contains age and sex. Model 3 contains age, sex, BMI, and LDL-C. Model 4 contains age, sex, BMI, LDL-C, T2DM status, hypertension status, CKD status, ever-smoking status, and statin treatment status. The HR is given either per 1 category increase in the categorized CERT score (4 categories = 4 steps) or per 1 step increase in the CERT score comprising 13 steps.