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. 2023 Oct 6;24(19):14947. doi: 10.3390/ijms241914947

Figure 2.

Figure 2

Melatonin and its metabolites reduced melanin content melanotic human MNT-1 melanoma cells. Cells were treated with MEL, AFMK, 5-MT and 6(OH)MEL for 72 h with 10−6 M (A) or 10−3 M (B) in comparison to melanogenic inhibitor, that is, 10−3 M PTU (positive control) and assessed as described in Materials and Methods. Data are presented as the mean + S.E.M. (n = 5) and values are normalized and expressed as percentage of the control value. Statistically significant differences are indicated as ** p < 0.01, *** p < 0.001, n.s.—not significant.