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. Author manuscript; available in PMC: 2024 Sep 11.
Published in final edited form as: Curr Biol. 2023 Aug 7;33(17):3660–3668.e4. doi: 10.1016/j.cub.2023.07.043

Figure 1. Activation of broadly expressing 104y neurons promotes seizures and paralysis.

Figure 1.

(A) Thermogenetic activation of 104y neurons from ZT0–6 causes persistent immobility for hours beyond the duration of the heat pulse. N≥26 for each group. (B) Thermogenetic activation of 104y neurons prevents animals from responding to strong mechanical agitation at ZT1. N≥38 for each group. (C-E) Expression of GFP in (C) anterior, (D) posterior, and (E) an inset of posterior brain depicting the dFB. C-D are max projections of whole mounts. E shows zoomed-in dFB from D. ****, p<.0001 by one-way ANOVA. Scale bars = 40 um. See also Videos S1 and S2.