Table 2.
Main clinical features of patients with GCA in whom a PET-CT was performed according to the clinical phenotype: classic cranial LVV-GCA or extracranial LVV-GCA.
| Classic Cranial LVV-GCA Phenotype | Extracranial LVV-GCA Phenotype | p | |
|---|---|---|---|
| n = 13 | n = 41 | ||
| Age at diagnosis (mean ± SD) | 75.5 ± 7.6 | 68.1 ± 9.9 | 0.017 |
| Women, n (%) | 12 (92.3) | 31 (75.6) | 0.26 |
| Positive biopsy and/or US of TA, n (%) | 13 (100) | 0/22 * (0) | <0.001 |
| Delay to diagnosis weeks (median [IQ range]) | 4 (3–8) | 12 (4–18) | 0.006 |
| Headache, n (%) | 12 (92.3) | 1 (2.4) | <0.001 |
| Scalp tenderness (%) | 2 (15.4) | 0 (0) | 0.055 |
| Abnormal temporal artery on physical examination, n (%) | 2 (15.4) | 0 (0) | 0.055 |
| Jaw claudication, n (%) | 2 (15.4) | 0 (0) | 0.055 |
| Polymyalgia rheumatica, n (%) | 2 (15.4) | 19 (46.3) | 0.057 |
| Visual manifestations, n (%) | 4 (30.8) | 0 (0) | 0.002 |
| Permanent visual loss, n (%) | 2 (15.4) | 0 (0) | 0.055 |
| Constitutional syndrome, n (%) | 12 (92.3) | 32 (78.0) | 0.42 |
| Fever > 38 °C | 1 (7.7) | 11 (26.8) | 0.25 |
| Arthralgia/myalgia | 6 (46.2) | 21 (51.2) | 0.75 |
| ESR mm/1st hour (mean ± SD) | 101 (71–120) | 68 (39–119) | 0.12 |
| ESR > 40 mm/1st hour at diagnosis, n (%) | 12 (90) | 28 (68) | 0.15 |
| CRP mg/dL (mean ± SD) | 3.8 (2.6–7.9) | 3.0 (1.0–7.6) | 0.43 |
| Hemoglobin g/dL (mean ± SD) | 11.6 ± 1.3 | 12.3 ± 1.6 | 0.072 |
| Platelets × 1000/mm3 (mean ± SD) | 410 ± 134 | 370 ± 147 | 0.25 |
TA: temporal artery. US: ultrasonography. * Number of patients in whom a TA or US of the TA was performed.