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. 1998 May;42(5):1015–1021. doi: 10.1128/aac.42.5.1015

TABLE 3.

Effects of IPM and CAZ on lethality for GalN-sensitized C3H/HeN and C3H/HeJ mice infected with P. aeruginosaa

Mouse strain Treatment (dose [mg/kg]) No. of survivors/total no. of mice (%)
C3H/HeN Saline 5/10 (50)
IPM (20) 8/8 (100)
CAZ (20) 0/10 (0)
C3H/HeJ Saline 9/16 (56)
IPM (20) 16/16 (100)
CAZ (20) 7/16 (44)
a

Groups of C3H/HeN and C3H/HeJ mice were injected i.p. with CAZ (20 mg/kg), IPM (20 mg/kg), or saline and were immediately inoculated i.p. with P. aeruginosa organisms (3 × 106 and 6 × 106 CFU/mouse, respectively); the mice were injected i.p. with 18 mg of GalN 105 min later.