TABLE 3.
Effects of IPM and CAZ on lethality for GalN-sensitized C3H/HeN and C3H/HeJ mice infected with P. aeruginosaa
| Mouse strain | Treatment (dose [mg/kg]) | No. of survivors/total no. of mice (%) |
|---|---|---|
| C3H/HeN | Saline | 5/10 (50) |
| IPM (20) | 8/8 (100) | |
| CAZ (20) | 0/10 (0) | |
| C3H/HeJ | Saline | 9/16 (56) |
| IPM (20) | 16/16 (100) | |
| CAZ (20) | 7/16 (44) |
Groups of C3H/HeN and C3H/HeJ mice were injected i.p. with CAZ (20 mg/kg), IPM (20 mg/kg), or saline and were immediately inoculated i.p. with P. aeruginosa organisms (3 × 106 and 6 × 106 CFU/mouse, respectively); the mice were injected i.p. with 18 mg of GalN 105 min later.