Figure 4.

The density of PV⁺ interneurons was reduced in the CA2 subfield following PILO-SE. A₁–B₂, Representative hippocampal sections from control (above) and PILO-SE (below) mice, stained for PV (green and white) to visualize PV⁺ interneurons, Nissl to label neuronal somata (blue), and PCP4 (red) to delineate the CA2 subfield. The bounds of the CA2 region were drawn across all layers of each hippocampal section (A₂, yellow dashed lines) and the density of PV⁺ interneurons was measured for each layer (see Materials and Methods). Scale bars, 150 µm. C, The density of PV⁺ INs in CA2 was reduced in the SO and SP layers in sections from PILO-SE mice.