Table 2.

CAR-T cell therapy related examination for management of toxicities.

Classification of Examination	Specific Examination and Tests
Regular laboratory examination	Blood routine; blood biochemistry; coagulation function test; arterial blood gas analysis; infection-related test; cytokines (IL-1, IL-2, IL-6, TNF-α, IFN-γ, etc.)
Regular imaging examination	Chest and abdomen enhanced CT; cerebral enhanced MRI; abdominal ultrasound; echocardiogram
Proliferation of CAR-T cells in vivo	Quantitative PCR detection of peripheral blood CAR gene; flow cytometry
Examination of organ function	Electrocardiogram; echocardiogram; systemic, superficial lymph node ultrasound; lung function test; CARTOX-10 scoring; electroencephalogram; cerebrospinal fluid pressure; abdominal ultrasound; (regular laboratory examination is helpful to assess organ function)

CAR-T-cell therapy associated toxicity-10 (CARTOX-10).