Table 1.

Measurements of hematological values of RBCs in the presence of [Pt^II(dien)(N7-Guo)]²⁺ (1), [Pt^II(dien)(N7-dGuo)]²⁺ (2), and [Pt^II(dien)(N7-dGTP)] (3) complexes at 10 mM concentration and at 5, 24, 48, and 72 h after treatment (dien = diethylenetriamine; Guo = guanosine; dGuo = 2′-deoxy-guanosine; dGTP = 5′-(2′-deoxy)-guanosine-triphosphate).

5 h	RBCs 106/μl	HGB g/dL	HCT %	MCV fl	MCH pg	MCHC g/dL
(0) 500 µL RBCs (NT)	5.30 ± 0.1	15.2 ± 0.55	44.6 ± 045	87 ± 1.0	31.6 ± 0.47	33.9 ± 1.4
(1) 500 µL RBCs + 1	4.87 ± 0.25	15.8 ± 0.30	44.3 ± 0.47	87 ± 1.0	30.9 ± 0.4	35.3 ± 0.32
(2) 500 µL RBCs + 2	4.67 ± 0.26	13.5 ± 0.4	39.7 ± 0.3	85 ± 0.58	30.7 ± 0.9	35.2 ± 0.55
(3) 500 µL RBCs + 3	4.85 ± 0.12	14.4 ± 0.4	40.7 ± 0.83	87 ± 0.5	29.9 ± 0.15	34.7 ± 0.46
24 h
(0) 500 µL RBCs (NT)	5.11 ± 0.08	15.4 ± 0.1	44.3 ± 0.47	87 ± 1.0	30.7 ± 0.5	35.1 ± 0.1
(1) 500 µL RBCs + 1	4.88 ± 0.07	14.2 ± 0.25	44.5 ± 0.4	85 ± 0.57	30.3 ± 0.61	35.3 ± 0.3
(2) 500 µL RBCs + 2	4.64 ± 0.07	13.9 ± 0.4	39.7 ± 0.37	85 ± 1.0	29.8 ± 0.1	34.7 ± 0.55
(3) 500 µL RBCs + 3	4.41 ± 0.06	13.3 ± 0.3	37.7 ± 0.32	86 ± 0.57	29.5 ± 0.15	36.8 ± 0.36
48 h
(0) 500 µL RBCs (NT)	5.58 ± 0.09	16.9 ± 0.2	46.6 ± 1.25	85 ± 0.57	30.5 ± 0.45	35.1 ± 0.8
(1) 500 µL RBCs + 1	4.72 ± 0.16	14.6 ± 0.38	38.9 ± 0.15	83 ± 0.57	30.5 ± 0.58	36.4 ± 0.25
(2) 500 µL RBCs + 2	4.69 ± 0.1	13.5 ± 0.3	39.5 ± 0.23	83 ± 0.57	29.4 ± 0.15	35.1 ± 0.3
(3) 500 µL RBCs + 3	3.87 ± 0.13	11.5 ± 0.34	31.7 ± 0.45	83 ± 0.58	30.7 ± 0.35	36.8 ± 0.36
72 h
(0) 500 µL RBCs (NT)	4.35 ± 0.61	12.7 ± 0.45	32.6 ± 0.77	79 ± 1.00	30.7 ± 0.25	37.4 ± 0.81
(1) 500 µL RBCs + 1	3.85 ± 0.10	13.4 ± 0.21	26.9 ± 0.83	70 ± 0.58	34.7 ± 0.5	49.7 ± 0.8
(2) 500 µL RBCs + 2	3.64 ± 0.12	10.6 ± 0.2	32.1 ± 0.1	66 ± 1.00	32.3 ± 0.3	47.7 ± 1.6
(3) 500 µL RBCs + 3	1.38 ± 0.06	3.93 ± 0.25	9.7 ± 0.4	71 ± 1.00	29.8 ± 0.2	41.9 ± 0.25

RBCs, red blood cells; HGB, hemoglobin; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration.