Table 2.

Synthesis of 2-(4-acylfuran-2-yl)acetamides 3 by PdI₂/KI-catalyzed oxidative aminocarbonylation of 2-propargyl-1,3-dicarbonyl compounds 1 with secondary amines 2 ^a.

Entry	PdI2 (mol%)	1	2	3	Yield of 3 (%) b
1	1				72
2	0.33	1a	2a	3aa	55
3	1	1a			67
4	0.33	1a	2b	3ab	55
5	1	1a			75
6	0.33	1a	2c	3ac	58
7	1	1a			74
8	0.33	1a	2d	3ad	59
9	1	1a			54
10	1	1a			74
11	0.33	1a	2f	3af	61
12	1		2a		81
13	0.33	1b	2a	3ba	68
14	1		2a		67
15	0.33	1c	2a	3ca	58
16	1		2f		66
17	1		2a		68
18	0.33	1e	2a	3ea	62
19	1		2a		54
20	1		2f		48
					25
21	1		2a		70
22	0.33	1h	2a	3ha	58
23	1		2a		69
24	0.33	1i	2a	3ia	58
25	1		2a		68
26	0.33	1j	2a	3ja	63
27	1		2a		71
28	0.33	1k	2a	3ka	60
29	1		2a		67
30	0.33	1l	2a	3la	56
31	1		2a		57
32	1		2c		72
33	0.33	1n	2c	3nc	67

^a All reactions were carried out in MeCN as the solvent (0.20 mmol of 1 per mL of MeCN), in the presence of PdI₂ (1 mol% or 0.33 mol%), KI (KI:PdI₂ molar ratio = 100), and amine 2 (4 equiv) for 15 h, under 20 atm of a 4:1 mixture of CO–air. Substrate conversion was quantitative in all cases. ^b Isolated yield based on starting 1.